208519-13-5Relevant academic research and scientific papers
A practical, multigram synthesis of the 2-(2-(4-alkoxyphenyl)-5,7- dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of high affinity translocator protein (TSPO) ligands
Banister, Samuel D.,Wilkinson, Shane M.,Hanani, Raphy,Reynolds, Aaron J.,Hibbs, David E.,Kassiou, Michael
, p. 3780 - 3783 (2012)
A practical, multigram approach to the 2-(2-(4-alkoxyphenyl)-5,7- dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide (DPA) class of ligands targeting the translocator protein (TSPO) is described. This synthetic route offers several improvements over all previously described sequences, including the isolation of intermediates without resort to chromatography. The common precursor to the DPA class of high affinity TSPO ligands, N,N-diethyl-2-(2-(4- hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide, was produced in 40% yield over six steps, and was cleanly alkylated to give multigram quantities of several DPA analogues in 90-96% yield after recrystallization.
NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
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Page/Page column 128, (2008/12/07)
The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
