208519-99-7Relevant articles and documents
The Reaction of Lithium Trimethylsilyldiazomethane with Pyroglutamates - a Facile Synthesis of 6-Diazo-5-oxo-norleucine and Derivatives
Coutts, Ian G. C.,Saint, Robert E.
, p. 3242 - 3246 (2007/10/03)
The reaction of carbamate derivatives of pyroglutamic acid esters with the lithium salt of trimethylsilyldiazomethane below -100 deg C gives good yields of the corresponding substituted 6-diazo-5-oxo-norleucine esters; cleavage of Fmoc-substituted products provides a safe, convenient route to the parent acid.
Synthesis of Enantiomerically Pure Amino Acids Containing a 2-Amino-4-thiazolyl Side Chain
Patt, William C.,Skeean, Richard W.,Steinbaugh, Bruce A.
, p. 3097 - 3102 (2007/10/02)
Enantiomerically pure 2-amino-4-thiazolyl containing amino acids were readily synthesized from commercially available derivatives of aspartic acid and glutamic acid, via reaction with diazomethane and further cyclization with thiourea.