208519-99-7

Basic information

• Product Name: (S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester
• Synonyms: (S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester
• CAS NO: 208519-99-7
• Molecular Weight: 361.398
• Mol File: 208519-99-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester(208519-99-7)
• EPA Substance Registry System: (S)-2-tert-Butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester(208519-99-7)

Safety Data

• Hazardous Substances Data: 208519-99-7(Hazardous Substances Data)

Upstream product

• 113400-36-5 benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 30924-93-7 Boc-Glu-OBn 
• 186581-53-3 diazomethane 

Downstream Products

• 132286-82-9 (S)-4-(2-Amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-butyric acid benzyl ester 

Relevant articles and documents

The Reaction of Lithium Trimethylsilyldiazomethane with Pyroglutamates - a Facile Synthesis of 6-Diazo-5-oxo-norleucine and Derivatives

The reaction of carbamate derivatives of pyroglutamic acid esters with the lithium salt of trimethylsilyldiazomethane below -100 deg C gives good yields of the corresponding substituted 6-diazo-5-oxo-norleucine esters; cleavage of Fmoc-substituted products provides a safe, convenient route to the parent acid.