20863-86-9Relevant academic research and scientific papers
Phenylhomophthalimide-type NOS inhibitors derived from thalidomide
Noguchi, Tomomi,Sano, Hiroko,Shimazawa, Rumiko,Tanatani, Aya,Miyachi, Hiroyuki,Hashimoto, Yuichi
, p. 4141 - 4145 (2004)
Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.
Specific inhibitor of puromycin-sensitive aminopeptidase with a homophthalimide skeleton: Identification of the target molecule and a structure-activity relationship study
Komoda, Masato,Kakuta, Hiroki,Takahashi, Hiroyasu,Fujimoto, Yasuyuki,Kadoya, Shizuo,Kato, Fuminori,Hashimoto, Yuichi
, p. 121 - 131 (2007/10/03)
2-(2,6-Diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (2: PIQ-22) was found to be a potent and specific inhibitor of puromycin-sensitive aminopeptidase (PSA). Lineweaver-Burk plot analysis showed that PSA is inhibited by PIQ-22 in a non-competitive manner. Structure-activity relationship studies indicated that tautomerism of the imidobenzoylketone group in the cyclic imide moiety of the PIQ-22 skeleton is important for the inhibitory activity.
