208648-98-0Relevant academic research and scientific papers
Synthesis of (+/-) - oxohexahydrofuro[3,2-b]pyrroles (pyrrolidine-trans-lactones) using acyl-iminium chemistry
Macdonald, Simon J.F.,Spooner, Julie E.,Dowle, Michael D.
, p. 1375 - 1377 (2007/10/03)
In a new synthesis of pyrrolidine-trans-lactones, an acyliminium pyrrolidine reacts with silyl ketene acetals. This reaction selectively generates C2, C3 trans stereochemistry.
Differential oxidation of endocyclic enecarbamates. Synthesis of cyclic β-hydroxy-α-amino acids
Sugisaki, Claudia H.,Carroll, Patrick J.,Correia, Carlos Roque D.
, p. 3413 - 3416 (2007/10/03)
The differential oxidation of five and six-membered endocyclic enecarbamates was investigated employing m-CPBA, DMD, as well as enantioselectivc protocols such as the Kochi-Jacobsen-Katsuki's epoxidation and the Sharpless dihydroxylation. By this strategy the syntheses of β- hydroxyprolines and β-hydroxypipecolic acids were accomplished, X-Ray crystallographic analysis of the trans-β-hydroxypipecolic acid was instrumental to solve structural assignment conflicts.
