20865-67-2Relevant academic research and scientific papers
The X-ray crystal structure of 2,4-bis(4-methoxyphenoxy) pyrimidine
De, Amitabha,Biswas, Goutam,Muhonen, Heikki
, p. 157 - 158 (2008)
The X-ray crystal structure of 2,4-bis(4-methoxyphenoxy)pyrimidine, C 18H16N2O4 was stabilised by the hydrogen bonding and van der Waal forces. The C-N bond in the pyrimidine moiety is shortened indicating of im
Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes
Bhilare, Shatrughn,Murthy Bandaru, Siva Sankar,Shah, Jagrut,Chrysochos, Nicolas,Schulzke, Carola,Sanghvi, Yogesh S.,Kapdi, Anant R.
, p. 13088 - 13102 (2018/10/25)
A mild, general, and highly efficient catalytic etherification protocol for chloroheteroarenes was developed using the Pd/PTABS catalytic system. The protocol is selective for the etherification of chloroheteroarenes using a large variety of electron-rich and electron-deficient phenol bearing synthons which include inter alia biologically and commercially important estrone, estradiol, tyrosine, and several other molecules. The mildness of the new protocol is expected to be beneficial for the synthesis of complex drugs and drug intermediates offering late-stage modification of bioactive compounds.
HETEROARYL ETHERS AND PROCESSES FOR THEIR PREPARATION
-
Page/Page column 43, (2009/12/05)
The present invention relates to processes for the preparation of heteroaryl ethers. In some embodiments, the processes relate to cross coupling reactions between triazol-1-yloxy and triazol-1-yl heterocycles with aryl boronic acids. In a further aspect, this invention also relates to compounds that are useful for the treatment of oncological diseases or disorders, and for the treatment of inflammation.
