208655-03-2

Upstream product

• 208655-02-1 2-(4-fluorophenyl)-3-oxo-3-pyridin-4-ylpropionic acid ethyl ester 
• 17356-08-0 thiourea 

Downstream Products

• 208655-00-9 5-(4-fluorophenyl)-3-methyl-2-methylthio-6-(pyridin-4-yl)-3H-pyrimidin-4-one 
• 208655-04-3 5-(4-fluorophenyl)-2-methylthio-6-(4-pyridyl)-4(3 H)-pyrimidinone 
• 208653-62-7 5-(4-Fluorophenyl)-2-hydrazino-6-(4-pyridyl)-4(3 H)-pyrimidinone 

Relevant academic research and scientific papers

From imidazoles to pyrimidines: New inhibitors of cytokine release

On the basis of model imidazole inhibitors of cytokine release, a series of novel pyridinyl pyrimidine derivatives was prepared and tested on their ability to inhibit the release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) from periphera

Substituted pyrimidinone and pyridone compounds and methods of use

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.