208655-24-7Relevant academic research and scientific papers
An efficient one-pot construction of substituted pyrimidinones
Lu, Yuelie,Xiang, Tingjian,Bartberger, Michael D.,Bernard, Charles,Bostick, Tracy,Huang, Liang,Liu, Longbin,Siegmund, Aaron,Sukay, Gregory,Guo, Gary,Elipe, Maria Silva,Tormos, Wanda,Dominguez, Celia,Koch, Kevin,Burgess, Laurence E.,Basil, Thomas C.,Ibrahim, Prabha,Hummel, Conrad
, p. 11714 - 11723 (2007/10/03)
A concise, scaleable synthesis of building block 10 for p38 kinase inhibitor B is described. The key step is the one-pot construction of 5-aryl-3-methyl-2-methylsulfanyl-6-pyridin-4-yl-3H-pyrimidin-4-one 4 from arylacetic acid ethyl ester 1. Subsequent hy
