20866-48-2

Basic information

• Product Name: BOC-TYR(BOC)-OH
• Synonyms: N,O-DI-BOC-L-TYROSINE;N,O-DI-T-BUTOXYCARBONYL-L-TYROSINE;N,O-BIS-BOC-L-TYROSINE;N-ALPHA,O-BIS-TERT-BUTYLOXYCARBONYL-L-TYROSINE;BOC-TYROSINE(BOC)-OH;BOC-TYR(BOC)-OH;BOC-L-TYR(BOC)-OH;N-ALPHA,O-BIS-T-BUTYLOXYCARBONYL-L-TYROSINE
• CAS NO: 20866-48-2
• Molecular Formula: C₁₉H₂₇NO₇
• Molecular Weight: 381.42
• Product Categories: Amino Acids
• Mol File: 20866-48-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 94-97 °C
• Boiling Point: 528.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.183±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 2.92±0.10(Predicted)
• CAS DataBase Reference: BOC-TYR(BOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-TYR(BOC)-OH(20866-48-2)
• EPA Substance Registry System: BOC-TYR(BOC)-OH(20866-48-2)

Safety Data

• Hazardous Substances Data: 20866-48-2(Hazardous Substances Data)

Usage

General Description

Boc-Tyr(Boc)-OH is a chemical compound that consists of a protected tyrosine amino acid. It is commonly used in organic synthesis and peptide chemistry as it allows for the protection of the tyrosine side chain during peptide assembly. The compound features a Boc (tert-butoxycarbonyl) group attached to the amino group of tyrosine and another Boc group attached to the hydroxyl group. This protection strategy helps to prevent unwanted reactions during the synthesis of peptides and ensures that the tyrosine residue is properly incorporated into the peptide chain. Boc-Tyr(Boc)-OH is a versatile building block for the preparation of various peptides and can be deprotected under mild acidic conditions to reveal the free tyrosine residue. Overall, Boc-Tyr(Boc)-OH is an important tool for peptide chemistry and is widely used in the synthesis of bioactive peptides and pharmaceutical compounds.

Upstream product

• 60-18-4 L-tyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3978-80-1 Boc-Tyr-OH 

Downstream Products

• 20866-53-9 Boc₂-Tyr-ONSu 
• 390815-84-6 carbonic acid 4-((S)-2-tert-butoxycarbonylamino-4-diazo-3-oxo-butyl)-phenyl ester tert-butyl ester 
• 113807-32-2 N,O-di-Boc-L-tyrosyl-D-alanyl-L-phenylalanyl-glycine 
• 113807-33-3 N,O-di-Boc-L-tyrosyl-D-alanyl-L-phenylalanyl-glycine pentafluorophenyl ester 
• 1184949-87-8 cis-2-(2,2-dimethoxyethyl)-4,5-di(O,N-diBoc-L-tyrosyloxymethyl)-1,3-dithiolane 

Relevant articles and documents

GLUCOSAMINE DERIVATIVES AND PHARMACEUTICAL USES THEREOF

There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Sequential Intermolecular Radical Addition and Reductive Radical Cyclization of Tyrosine and Phenylalanine Derivatives with Alkenes via Photoinduced Decarboxylation: Access to Ring-Constrained γ-Amino Acids

Sequential radical addition to alkenes and reductive radical cyclization of phenylalanine and tyrosine derivatives via photoinduced decarboxylation furnished ring-constrained γ-amino acids under mild conditions. A variety of alkenes such as acrylamides and acrylic esters could be employed in the photoinduced radical cascade cyclization. The yields of the ring-constrained γ-amino acids are dependent on the electron-accepting ability and steric hindrance of the alkene used. The proposed sequential reaction can also be applied for direct tethering of dipeptides to yield unique ring-constrained tetrapeptides.

New precursors for direct radiosynthesis of protected derivatives of O-([18F]Fluoromethyl) tyrosine

The invention describes novel and stable precursors for the direct radiosynthesis of protected derivatives of O-([18F]Fluoromethyl) tyrosines, and methods for obtaining thoses compounds.