2086772-26-9 Usage
Uses
Used in Oncology:
JNJ-64619178 is used as an anticancer agent for the treatment of various cancers, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC). It targets the bromodomain and extra-terminal (BET) family of proteins, disrupting the transcriptional regulation of oncogenes and cancer-related genes, ultimately leading to the suppression of tumor growth and proliferation.
Used in Combination Therapy:
JNJ-64619178 is used in combination with other anticancer agents to enhance the therapeutic effects and overcome drug resistance in cancer treatment. Its synergistic effects with other agents highlight its potential as a valuable component in multimodal cancer therapy approaches. Further clinical research is needed to fully understand the efficacy and safety of JNJ-64619178 in treating cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 2086772-26-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,8,6,7,7 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2086772-26:
(9*2)+(8*0)+(7*8)+(6*6)+(5*7)+(4*7)+(3*2)+(2*2)+(1*6)=189
189 % 10 = 9
So 2086772-26-9 is a valid CAS Registry Number.
2086772-26-9Relevant academic research and scientific papers
NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
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, (2017/03/14)
The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
