208709-79-9

Upstream product

• 208709-78-8 [(S)-1-(2-Cyano-ethylcarbamoyl)-4-(2-methoxy-phenyl)-but-3-ynyl]-carbamic acid tert-butyl ester 

Downstream Products

• 208709-81-3 {[(S)-1-[1-(2-Cyano-ethyl)-1H-tetrazol-5-yl]-4-(2-methoxy-phenyl)-but-3-ynylamino]-methyl}-phosphonic acid diphenyl ester 
• 208709-82-4 {[(S)-4-(2-Methoxy-phenyl)-1-(1H-tetrazol-5-yl)-but-3-ynylamino]-methyl}-phosphonic acid diphenyl ester 
• 208709-80-2 3-{5-[(S)-1-Amino-4-(2-methoxy-phenyl)-but-3-ynyl]-tetrazol-1-yl}-propionitrile 

Relevant academic research and scientific papers

Design and synthesis of potent, selective inhibitors of endothelin- converting enzyme

Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion of its precursor by endothelin-converting enzyme-1 (ECE-1), a metalloprotease which displays high