208710-05-8Relevant articles and documents
Design and synthesis of potent, selective inhibitors of endothelin- converting enzyme
Wallace, Eli M.,Moliterni, John A.,Moskal, Michael A.,Neubert, Alan D.,Marcopulos, Nicholas,Stamford, Lisa B.,Trapani, Angelo J.,Savage, Paula,Chou, Mary,Jeng, Arco Y.
, p. 1513 - 1523 (2007/10/03)
Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date. The final step of posttranslational processing of this peptide is the conversion of its precursor by endothelin-converting enzyme-1 (ECE-1), a metalloprotease which displays high