208756-00-7Relevant articles and documents
Synthesis of β-difluorine-containing amino acids
Li, Keqiang,Leriche, Caroline,Liu, Hung-Wen
, p. 1097 - 1100 (1998)
A convenient strategy was developed to prepare several β-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine, 3,3- difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reaction sequence all started from L-isoascorbic acid. This approach holds potential to be extended to make other β-difluorine-containing amino acids.