208758-62-7Relevant academic research and scientific papers
Synthesis and triplex forming properties of an acyclic N7-glycosylated guanine nucleoside
St. Clair, Aimee,Xiang, Guobing,McLaughlin, Larry W.
, p. 925 - 937 (2007/10/03)
A chiral acyclic nucleoside, one in which the ribose carbohydrate has been replaced with a glycerol-based linker, is prepared by glycosylating guanine at the N7-nitrogen. The stereochemically pure derivative is converted to a DMT-protected phosphoramidite for incorporation into DNA sequences. Sequence containing the acyclic N7-dG nucleoside are capable of forming DNA triplexes in which it is likely that the N1-H and N2-amino groups of the N7-dG are involved in recognition of the guanine base in G-C base pairs.
