208921-60-2

Basic information

• Product Name: 4-chloro-N-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine
• Synonyms: 4-chloro-N-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine
• CAS NO: 208921-60-2
• Molecular Weight: 295.731
• Mol File: 208921-60-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine(208921-60-2)
• EPA Substance Registry System: 4-chloro-N-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-1-amine(208921-60-2)

Safety Data

• Hazardous Substances Data: 208921-60-2(Hazardous Substances Data)

Upstream product

• 51347-93-4 2‐chloro‐3‐hydrazinylquinoxaline 
• 103-72-0 phenyl isothiocyanate 
• 2213-63-0 2,3-dichloroquinoxaline 

Relevant articles and documents

Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach

Imiquimod (1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine) is efficacious in topical therapy for certain types of skin cancers. Structurally similar EAPB0203 (N-methyl-1-(2-phenethyl)imidazo[1,2-a]quinoxalin-4-amine) has been shown higher in vitro potency than imiquimod. Besides, triazole, oxadiazole, and thiadiazole rings are privileged building blocks in drug design. A series of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole and [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-thiadiazole derivatives were therefore synthesized by incorporation of these rings into the structure of EAPB0203 and assessed their antiproliferative effects against various cancer cell lines. The 1,3,4-oxadiazole derivatives demonstrated the superior effectiveness compared to imiquimod and EAPB0203. Our findings highlight the excellent potential of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as anticancer agents.