208932-52-9Relevant academic research and scientific papers
Solid-phase synthesis of oligoesters using a JandaJel resin
Brümmer, Oliver,Clapham, Bruce,Janda, Kim D.
, p. 2257 - 2259 (2001)
This communication describes a general method for the solid-phase synthesis of oligomeric esters. A JandaJel resin was utilized as the solid support in conjunction with the highly acid labile Rink linker. Ester coupling reactions were performed using buff
Cysteine-based mannoside glycoclusters: Synthetic routes and antiadhesive properties
Schierholt, Alexander,Hartmann, Mirja,Schwekendiek, Kirsten,Lindhorst, Thisbe K.
scheme or table, p. 3120 - 3128 (2010/08/19)
Clustermannosides of different valency were synthesised based on cysteine. By employing the orthogonally protected amino acid as scaffold molecule, a variety of structurally varied products can be obtained according to different synthetic routes. Testing of the prepared glycoclusters as inhibitors of type 1 fimbriae mediated bacterial adhesion is reported, giving hints about the influence of sugar valency, sugar scaffolding, and the nature of the glycosidic aglycon in this testing system.
Design and synthesis of phosphotyrosine peptidomimetic prodrugs
Garrido-Hernandez, Hugo,Moon, Kyung D.,Geahlen, Robert L.,Borch, Richard F.
, p. 3368 - 3376 (2007/10/03)
A novel approach to the intracellular delivery of aryl phosphates has been developed that utilizes a phosphoramidate-based prodrug approach. The prodrugs contain an ester group that undergoes reductive activation intracellularly with concomitant expulsion
