208938-45-8

Basic information

• Product Name: ((S)-2-Hydroxy-1-methyl-1-phenyl-ethyl)-carbamic acid tert-butyl ester
• CAS NO: 208938-45-8
• Molecular Weight: 251.326
• Mol File: 208938-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-2-Hydroxy-1-methyl-1-phenyl-ethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-2-Hydroxy-1-methyl-1-phenyl-ethyl)-carbamic acid tert-butyl ester(208938-45-8)
• EPA Substance Registry System: ((S)-2-Hydroxy-1-methyl-1-phenyl-ethyl)-carbamic acid tert-butyl ester(208938-45-8)

Safety Data

• Hazardous Substances Data: 208938-45-8(Hazardous Substances Data)

Upstream product

• 208938-37-8 tert-Butyl-((S)-2-isocyanato-2-phenyl-propoxy)-dimethyl-silane 
• 208938-35-6 (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionic acid 
• 208938-33-4 (S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-2-phenyl-propionaldehyde 
• 13398-55-5 (S)-4-methyl-4-phenyloxazolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 84311-18-2 (R)-2-N-(tert-butoxycarbonyl)amino-2-methyl-3-hydroxy-propanoic acid 

Relevant articles and documents

Asymmetric synthesis of α,α-disubstituted α-amino acide derivatives using MABR promoted rearrangement

An efficient route for the asymmetric synthesis of α,α-disubstituted α-amino acids derivatives (1, 2, and 3) starting from readily available epoxy silyl ethers (6) has been developed. High enantiomeric purity can be realized by the present method using a combination of MABR rearrangement of a chiral epoxide and Curtius rearrangement.