208987-63-7Relevant academic research and scientific papers
Synthesis and antibacterial activities or new carbapenems having a proline reverse amide moiety at the C-2 position
Hwang, Soon Ho,Shin, Kye Jung,Kang, Yong Koo,Kim, Dong Jin,Kim, Dong Chan,Yoo, Kyung Ho,Park, Sang Woo,Lee, Kee Jung
, p. 139 - 142 (1998)
The synthesis of new 1β-methylcarbapenems (1a-l) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-h) are found to show greater antibacterial activity than aromatic amides (1i-l). Moreover, C-2 free amino compound (1m) reveals greater activity than any other amide compounds (1a-l).
