209047-47-2Relevant academic research and scientific papers
Synthesis of 5′-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives
Ohkubo, Akihiro,Tago, Nobuhiro,Yokouchi, Akira,Nishino, Yudai,Yamada, Ken,Tsunoda, Hirosuke,Seio, Kohji,Sekine, Mitsuo
, p. 10 - 13 (2012)
Trivalent phosphoramidite derivatives could be readily converted by reacting with 1-hydroxy-7-azabenzotriazole to phosphotriester intermediates; these intermediates reacted smoothly with phosphorylated compounds to give pyrophosphate derivatives. This new
Synthesis of new aminoacyl-adenylate analogs having an N-acyl phosphoramidate linkage
Moriguchi, Tomohisa,Yanagi, Terukazu,Wada, Takeshi,Sekine, Mitsuo
, p. 3725 - 3728 (2007/10/03)
New aminoacyl-adenylate analogs (aa-AMPNs), in which the oxygen atom of the mixed anhydride bond of aminoacyl-adenylates is replaced by an NH group, were synthesized by the reaction of an adenosine 5'-phosphoramidite derivative with appropriately protected amino acid amides. Among various reagents studied for activation of the 5'-phosphoramidite derivative, 5-(4- nitrophenyl)-1H-tetrazole was found to give N-acyl phosphoramidate derivatives in good yields.
