209160-23-6

Basic information

• Product Name: (2R,3S,6S)-3-Methyl-4-oxo-6-phenyl-piperidine-1,2-dicarboxylic acid 2-methyl ester 1-(2,2,2-trichloro-ethyl) ester
• Synonyms: (2R,3S,6S)-3-Methyl-4-oxo-6-phenyl-piperidine-1,2-dicarboxylic acid 2-methyl ester 1-(2,2,2-trichloro-ethyl) ester
• CAS NO: 209160-23-6
• Molecular Weight: 422.693
• Mol File: 209160-23-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S,6S)-3-Methyl-4-oxo-6-phenyl-piperidine-1,2-dicarboxylic acid 2-methyl ester 1-(2,2,2-trichloro-ethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,6S)-3-Methyl-4-oxo-6-phenyl-piperidine-1,2-dicarboxylic acid 2-methyl ester 1-(2,2,2-trichloro-ethyl) ester(209160-23-6)
• EPA Substance Registry System: (2R,3S,6S)-3-Methyl-4-oxo-6-phenyl-piperidine-1,2-dicarboxylic acid 2-methyl ester 1-(2,2,2-trichloro-ethyl) ester(209160-23-6)

Safety Data

• Hazardous Substances Data: 209160-23-6(Hazardous Substances Data)

Upstream product

• 209160-19-0 (2R,3S,6S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-4-oxo-6-phenyl-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 209160-21-4 (2R,3S,6S)-2-Hydroxymethyl-3-methyl-4-oxo-6-phenyl-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 181528-77-8 (2R,3S,6S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-methyl-6-phenyl-piperidin-4-one 
• 181783-40-4 (-)-(2R,3S,6S)-2-hydroxymethyl-3-methyl-6-phenyl-4-piperidone 
• 186581-53-3 diazomethane 

Relevant articles and documents

Enantioselective Synthesis of Substituted Pipecolic Acid Derivatives

Enantiomerically pure 4-piperidones, prepared by asymmetric [4 + 2] Diels-Alder cycloadditon of chiral 2-aminodienes with imines, have been used as starting materials for the synthesis of several derivatives of pipecolic acid. The α-amino acid moiety is obtained after the oxidation of a hydroxy group or a furan ring of a conveniently protected 2-aryl-6-(hydroxymethyl)-4-piperidone. Depending on the starting piperidone and the synthetic strategy, it is possible to obtain D- or L-functionalized pipecolic acid derivatives by a short synthetic procedure. Moreover, a stereoselective epimerization of the α-carbon atom of a particular pipecolate allows for the preparation of both cis- and trans-6-(hydroxymethyl)pipecolic acids, structures related with dipeptide isosteres.