209173-75-1

Upstream product

• 582-33-2 3-aminobenzoic acid ethyl ester 
• 93-11-8 2-Naphthalenesulfonyl chloride 

Downstream Products

• 358673-18-4 N-{2-methoxy-5-[1,6,6-tris-(3-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-4-methoxy-phenyl)-1,6-bis-(3-methylamino-phenyl)-hexa-2,4-diynyl]-benzyl}-N,N',N'-trimethyl-ethane-1,2-diamine 
• 358673-14-0 C₇₂H₅₆N₂O₁₂S₂ 
• 413620-79-8 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide 
• 358673-12-8 C₆₈H₅₆N₂O₈S₂ 
• 358673-16-2 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide 
• 550372-00-4 C₄₈H₄₄N₂O₄ 
• 358673-10-6 naphthalene-2-sulfonic acid {3-[1,1-bis-(4-methoxy-phenyl)-prop-2-ynyl]-phenyl}-methyl-amide 
• 358673-08-2 naphthalene-2-sulfonic acid {3-[hydroxy-bis-(4-methoxy-phenyl)-methyl]-phenyl}-methyl-amide 
• 358673-06-0 3-[methyl-(naphthalene-2-sulfonyl)-amino]-benzoic acid ethyl ester 

Relevant academic research and scientific papers

Cooperative ratiometric chemosensors: Pinwheel receptors with an integrated fluorescence system

The synthesis and fluorescent properties of a second generation cooperative chemical sensor are described. The sensor has two interacting binding pockets for cooperative recognition of two analytes. Cooperative binding activates a ratiometric fluorescent response via formation of an excimer. Binding was characterized by NMR, absorption, and fluorescence spectroscopy. The advantages of separating the recognition elements from the fluorescent response elements are discussed.

NOVEL SULFONE AMIDE DERIVATIVES CAPABLE OF INHIBITING BACE

The present invention relates to novel derivatives of sulfone amide of Formula 1 as defined in this disclosure which inhibit the activity of BACE (or beta-secretase). These sulfone amide derivatives are useful for the treatment and prevention of Alzheimer's disease and related diseases caused by production of beta-amyloid, by inhibiting the activity of BACE.

Substituted benzamides, their production and their use as cysteine protease inhibitors

Benzamides of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: R1—C1-C6/sub