20921-96-4

Basic information

• Product Name: METHYL (2-CYANOPHENYL)ACETATE
• Synonyms: (2-CYANO-PHENYL)-ACETIC ACID METHYL ESTER;METHYL (2-CYANOPHENYL)ACETATE;Benzeneacetic acid, 2-cyano-, Methyl ester;Methyl 2-(2-cyanophenyl)acetate;2-Cyanobenzeneacetic acid methyl ester
• CAS NO: 20921-96-4
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Product Categories: pharmacetical
• Mol File: 20921-96-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 273.8 °C at 760 mmHg
• Flash Point: 123.7 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.00561mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• CAS DataBase Reference: METHYL (2-CYANOPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (2-CYANOPHENYL)ACETATE(20921-96-4)
• EPA Substance Registry System: METHYL (2-CYANOPHENYL)ACETATE(20921-96-4)

Safety Data

• Hazardous Substances Data: 20921-96-4(Hazardous Substances Data)

Usage

Uses

Methyl 2-(2-Cyanophenyl)acetate can be used as WEE1 kinase inhibitors to treat cancer and other proliferative diseases.

InChI:InChI=1/C10H9NO2/c1-13-10(12)6-8-4-2-3-5-9(8)7-11/h2-5H,6H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 18698-99-2 2-(2-cyanophenyl)acetic acid 
• 67-56-1 methanol 
• 1477-50-5 Indole-2-carboxylic acid 
• 39203-20-8 methyl 1H-indole-1-carboxylate 
• 942-24-5 3-methoxycarbonylindole 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 529-19-1 2-Methylbenzonitrile 
• 79-22-1 methyl chloroformate 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 18698-96-9 o-iodophenylacetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 3342-78-7 2-(2-aminophenyl)acetic acid 
• 18698-97-0 ortho-bromophenylacetic acid 

Downstream Products

• 40851-66-9 2-(tert-butoxycarbonylaminomethyl)phenylacetic acid 
• 147410-31-9 methyl 2-(N-(tert-butoxycarbonyl)aminomethyl)phenylacetate 
• 1092794-06-3 1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester 
• 1092794-25-6 2'H-spiro[cyclopropane-1,1'-isoquinolin]-3'(4'H)-one 
• 1216947-34-0 methyl 2-(2-(5,6,7,8-tetrahydroisoquinolin-3-yl)phenyl)acetate 
• 1216947-32-8 methyl 2-(2-(6,7-dihydro-5H-cyclopenta[c]pyridin-3-yl)phenyl)acetate 
• 1231755-75-1 methyl 2-(2-cyanophenyl)acrylate 
• 561297-87-8 7’-nitro-2’,3’-dihydro-1’H-spiro[cyclopropane-1,4’-isoquinoline] 

Relevant articles and documents

Synthesis, biological evaluation and molecular docking studies of novel 2-(2-cyanophenyl)-N-phenylacetamide derivatives

A series of novel 2-(2-cyanophenyl)-N-phenylacetamide derivatives 3(a-u) were designed and synthesized via selective amidation of methyl-2-(2-cyanophenyl)acetates over amidine formation by using AlMe3 as catalyst in good yields. All the newly s

1, 2 - DIHYDRO- 3H- PYRAZOLO [3, 4 - D] PYRIMIDIN -3 - ONE ANALOGS

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

Expedient drug synthesis and diversification via ortho-C-H iodination using recyclable PdI2 as the precatalyst

(Figure Presented) Pd(II)-catalyzed ortho-C-H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI2 as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib.