209215-55-4Relevant articles and documents
VANADIUM INSULIN-MIMETICS, METHODS OF PREPARATION, AND METHODS FOR TREATMENT OF DIABETES
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Paragraph 102; 103; 104, (2019/01/05)
Disclosed are vanadyl complexes of Formula 1, Formula 2, and Formula 3, wherein Ri, R2, and R are defined as in the description. The pharmaceutical compositions containing these complexes and uses of the complexes for treatment of Diabetes Mellitus, such as Diabetes Mellitus Type 2, are also disclosed.
Studies on the mechanism of chelate degradation in iron-based, liquid redox H2S removal processes
Chen, Dian,Martell, Arthur E.,McManus, Derek
, p. 264 - 274 (2007/10/02)
Available data on the oxidation of nitrilotriacetic acid (NTA), ethylenedinitrilotetraacetic acid (EDTA), N-hydroxyethylethylenediaminetriacetic acid (HEDTA), and other aminopolycarboxylate chelating agents are reviewed and the intermediates and products of the oxidative degradation of each chelating agent are described and compared.The oxidation of these chelating agents occurs during the reoxidation of the ferrous chelatre to the ferric chelate, during which a Fenton type side reaction occurs in which hydrogen peroxides is formed and which in turn generates the hydroxyl radical by reaction with ferrous ion.The site of oxidative attack by the hydroxyl radical on these ligands seems to be the -CH2- groups α to the carboxylate groups, as well as the -CH2- groups in the ethylene bridges between the nitrogens.The evidence for the implication of the hydroxyl radical as the active oxidant is discussed, and the use of phenyl-tert-butylnitrone (PBN) as the trapping agent for the hydroxyl radical is described.The use of chelating agents as Fe3+/Fe2+ redox catalysts for the oxidation of H2S to sulfur that are less reactive toward the hydroxyl radical is recommended. Key words: chelate degradation, H2S oxidation, nitrilotriacetic acid (NTA), ethylenedinitrilotetraacetic acid (EDTA), N-hydroxyethylethylenediaminetriacetic acid (HEDTA).