20924-63-4

Upstream product

• 610-99-1 1-(2-Hydroxy-phenyl)-propan-1-on 
• 4755-77-5 Ethyl oxalyl chloride 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 859404-05-0 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-carbamoyl-2-hydroxy-ethyl)-amide 
• 859404-01-6 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-isopropylcarbamoyl-ethyl)-amide 
• 859403-89-7 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide 
• 859403-93-3 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid ((1S,2R)-1-benzyl-2-hydroxy-2-phenethylcarbamoyl-ethyl)-amide 
• 859403-97-7 3-Methyl-4-oxo-4H-chromene-2-carboxylic acid [(1S,2R)-1-benzyl-2-hydroxy-2-(2-morpholin-4-yl-ethylcarbamoyl)-ethyl]-amide 
• 608095-64-3 1-phenylsulfanyl-1H-2,4-dioxa-cyclopenta[b]naphthalene-3,9-dione 
• 608095-63-2 4-oxo-3-phenylsulfanylmethyl-4H-chromene-2-carboxylic acid ethyl ester 
• 33544-08-0 3-methyl-4-oxo-4H-chromene-2-carboxylic acid amide 

Relevant academic research and scientific papers

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors

Excessive calpain activations contribute to serious cellular damage and have been found in many pathological conditions. Novel chromone carboxamides derived from ketoamides were prepared and evaluated for μ-calpain inhibition. Among synthesized, compound

A new regiospecific preparation of xanthones

(Matrix presented) Condensation of a benzopyranonphthalide with Michael acceptors provides an efficient, general method for regiospecific preparation of xanthones as well as linear and angular polycyclic aromatic systems containing a xanthone fragment.