209258-59-3Relevant academic research and scientific papers
Synthesis of constrained α-amino acid derivatives via diels-alder approach
Kotha, Sambasivarao,Brahmachary, Enugurthi,Sreenivasachary, Nampally
, p. 4095 - 4098 (1998)
Synthesis of new five and seven membered outer ring diene building blocks containing α-amino acid moiety and their usage in the preparation of the constrained amino acid derivatives is described.
Constrained phenylalanine derivatives by enyne metathesis and Diels-Alder reaction
Kotha, Sambasivarao,Sreenivasachary, Nampally,Brahmachary, Enugurthi
, p. 787 - 792 (2007/10/03)
A conceptually new approach for the synthesis of indane-based α-amino acid derivatives is reported. In this regard, the synthesis of five-membered exocyclic and five-membered inner-outer ring diene building blocks (7 and 15) containing α-amino acid moieties is described. Diene 15 is prepared by an enyne metathesis reaction as a key step. In this paper, a full account of our work regarding the Diels-Alder reaction of these dienes with various dienophiles, and the subsequent oxidation of the cycloadducts to give various indane-based α-amino acid derivatives is reported.
