209260-39-9

Upstream product

• 127793-64-0 (R)-1-O-(tert-butyldiphenylsilyl)-4-penten-1,2-diol 
• 184917-65-5 4,4-dimethyl-5-oxohept-2-enoic acid 
• 106921-60-2 2,2-dimethyl-3-oxopentanal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1026423-73-3 (R)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-butyraldehyde 
• 107033-46-5 (R)-(tert-butyldiphenylsilyloxy)methyloxirane 
• 184917-79-1 (E)-4,4-Dimethyl-5-oxo-hept-2-enoic acid tert-butyl ester 

Downstream Products

• 209260-24-2 (E)-(6R,7S,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 
• 209260-25-3 (E)-(6S,7R,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (R)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester 

Relevant academic research and scientific papers

The olefin metathesis approach to epothilone A and its analogues

The olefin metathesis approach to epothilone A (1) and several analogues (39-41, 42-44, 51-57, 58-60, 64-65, and 67-69) is described. Key building blocks 6-8 were constructed in optically active form and were coupled and elaborated to olefin metathesis pr

Durch Olefinmetathese zum Epothilongeruest

Keywords: Cyclisierungen; Epothilone; Naturstoffe; Olefinmetathese; Synthesemethoden