209262-59-9Relevant academic research and scientific papers
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors
Ukita, Tatsuzo,Sugahara, Masakatsu,Terakawa, Yoshihiro,Kuroda, Tooru,Wada, Kazuteru,Nakata, Aya,Kikkawa, Hideo,Ikezawa, Katsuo,Naito, Kazuaki
, p. 2347 - 2350 (2007/10/03)
A novel series of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives has been prepared. These compounds showed potent PDE4 inhibitory activities and a broad margin between the Ki value of the rolipram binding affinity and the IC50 value of PDE4 inhibition. They also exhibited potent inhibitory activities toward LPS-induced TNF-α production in mice.
