209325-04-2

Upstream product

• 209325-03-1 4-[9-(tert-butyldimethylsilyloxy)non-1-ynyl]-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman-4-ol 
• 209325-02-0 7-Methoxy-3-(4-methoxyphenyl)-3-methylthiochroman-4-one 
• 153004-34-3 9-(t-Butyldimethylsilyloxy)-non-1-yne 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 71268-70-7 7-((tert-butyldimethylsilyl)oxy)-1-bromoheptane 
• 10160-24-4 7-bromoheptyl alcohol 

Downstream Products

• 209325-05-3 4-[9-(t-butyldimethylsilyloxy)nonyl]-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman 

Relevant academic research and scientific papers

Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship

In order to develop pure antiestrogens, a series of 7-hydroxy-3-(4-hydroxyphenyl)-3-methylchroman and 7-hydroxy-3-(4-hydroxyphenyl)-3-methylthiochroman derivatives with sulfoxide containing side chains at the 4-position were designed, synthesized, and eva

Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens

In order to search for alternatives to the sulfoxide moiety in the long side chain of pure antiestrogens, several molecules that may interact with water in a fashion similar to ICI164,384 were designed and it was found that compounds with the carboxy, the

Benzopyran or thiobenzopyran derivatives

The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: The present invention further provides pharmaceutical compositions which possess anti-estrogenic activity and comprise at least one benzopyran compound of the invention and a method of treating breast cancer by administration of an effective amount of a benzopyran compound provided by the present invention.

Benzopyran derivatives

PCT No. PCT/KR97/00265 Sec. 371 Date Jun. 8, 1999 Sec. 102(e) Date Jun. 8, 1999 PCT Filed Dec. 13, 1997 PCT Pub. No. WO98/25916 PCT Pub. Date Jun. 18, 1998The present invention relates to a novel benzopyran derivative having anti-estrogenic activity. More