2093293-77-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 215789-45-0 trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetic acid methyl ester 
• 946598-34-1 trans 2-{1-[4-(N-(tert-butoxycarbonyl))amino]cyclohexyl}ethyl acetate 
• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 917342-29-1 trans 2-{1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl}ethanol 

Downstream Products

• 506427-91-4 trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]ethyl}-cyclohexylamine 
• 506427-91-4 trans N-tert-butoxycarbonyl-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexylamine 
• 1212272-05-3 tert-butyl ((1r,4r)-4-(2-aminoethyl)cyclohexyl)carbamate 

Relevant academic research and scientific papers

Preparation method of cariprazine

The invention provides a preparation method of cariprazine, which comprises the following steps: reacting trans-N-tert-butyloxycarbonyl-4-(2-(4-(2,3-dichlorophenyl)-piperazine-1-yl)-ethyl)-cyclohexylamine with dimethylamine under the conditions of an orga

Preparation method of cyclohexane derivative

The invention relates to a preparation method of a cyclohexane derivative. The preparation method comprises the following steps of (1) performing nucleophilic substitution reaction on a compound SM01and a compound SM02 or salts thereof to obtain a compound A; (2) deprotecting the compound A to obtain a compound B; (3) and performing acylation reaction on the compound B and an acylation reagent toobtain the cyclohexane derivative. The disclosed by the method has the advantages of being less in side reaction, high in product yield and purity, and beneficial to industrial scale production.

Compound for preparation of cariprazine and preparation method thereof

The invention relates to a compound for preparation of cariprazine and a preparation method thereof. The method can overcome the defects in the prior art, the used raw materials and reagents are low toxic, cheap and easily available, the reaction conditions are mild, fewer three wastes are generated, at the same time, the operation is simple and safe, and the yield is good, therefore the method is suitable for industrialized production.