2093409-57-3

Basic information

• Product Name: N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanamide
• CAS NO: 2093409-57-3
• Molecular Weight: 479.576
• Mol File: 2093409-57-3.mol

Chemical Properties

• Boiling Point: 765.8±60.0 °C(Predicted)
• Density: 1.23±0.1 g/cm3(Predicted)
• CAS DataBase Reference: N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanamide(2093409-57-3)
• EPA Substance Registry System: N-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethyl)-4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanamide(2093409-57-3)

Safety Data

• Hazardous Substances Data: 2093409-57-3(Hazardous Substances Data)

Upstream product

• 1353016-70-2 4-{2-azatricyclo[10.4.0.0⁴'⁹]hexadeca-1⁽¹⁶⁾,4⁽⁹⁾,5,7,12,14-hexaen-10-yn-2-yl}-4-oxobutanoic acid 
• 101187-40-0 1-Boc-amine-11-amino-3,6,9-trioxaundecane 
• 1353016-71-3 4-{2-azatricyclo[10.4.0.0⁴'⁹]hexadeca-1⁽¹²⁾,4⁽⁹⁾,5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid 

Relevant articles and documents

ANTIBODY-DRUG CONJUGATES CONTAINING AN ANTI-MESOTHELIN ANTIBODY AND USES THEREOF

The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

HETEROARYL SULFONE-BASED CONJUGATION HANDLES, METHODS FOR THEIR PREPARATION, AND THEIR USE IN SYNTHESIZING ANTIBODY DRUG CONJUGATES

The present invention is directed to novel heteroaryl sulfone-based conjugation handles of the formula: (wherein R1, R2, Het, D, E, X, Y, Z, m, n, p, q, r, s and t are as defined herein), methods for their preparation, their use in synthesizing antibody drig conjugates, and the resulting antibody drig conjugates made with components having heteroaryl sulfone- based conjugation handles.