209342-41-6

Basic information

• Product Name: Finafloxacin Hydrochloride
• Synonyms: Finafloxacin Hydrochloride;3-Quinolinecarboxylic acid, 8-cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-, Monohydrochloride (9CI);8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride;8-cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid monohydrochloride;8-Cyano-1-cyclopropyl-6-fluoro-7-((4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl)-4-oxo;FINAFLOXACIN HCL
• CAS NO: 209342-41-6
• Molecular Formula: C20H20ClFN4O4
• Molecular Weight: 434.8486032
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 209342-41-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 686.2°C at 760 mmHg
• Flash Point: 368.8°C
• Appearance: /
• Vapor Pressure: 9.03E-20mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Base (Very Slightly), DMSO (Slightly, Sonicated)
• Stability: Hygroscopic
• CAS DataBase Reference: Finafloxacin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Finafloxacin Hydrochloride(209342-41-6)
• EPA Substance Registry System: Finafloxacin Hydrochloride(209342-41-6)

Safety Data

• Hazardous Substances Data: 209342-41-6(Hazardous Substances Data)

Usage

Description

Finafloxacin Hydrochloride is a synthetic broad-spectrum antibiotic belonging to the fluoroquinolone class of antibiotics. It is characterized by its potent bactericidal activity against a wide range of gram-positive and gram-negative bacteria, including atypical pathogens. The hydrochloride salt form enhances its solubility and bioavailability, making it an effective pharmaceutical agent for treating various bacterial infections.

Uses

Used in Pharmaceutical Industry:
Finafloxacin Hydrochloride is used as an active pharmaceutical ingredient for the treatment of bacterial infections, particularly those caused by Helicobacter pylori. It is effective in eradicating the bacteria and alleviating the associated gastroduodenal illnesses, such as peptic ulcers and gastritis.
Used in Research and Development:
Finafloxacin Hydrochloride is also utilized in the preparation of naphthyridonecarboxylic acid derivatives, which are potential drugs for the therapy of Helicobacter pylori infections. These derivatives may offer improved efficacy, reduced side effects, or enhanced targeting of the bacteria, contributing to the development of novel treatment options for patients suffering from H. pylori-related illnesses.

InChI:InChI=1/C20H19FN4O4.ClH/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15;/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28);1H/t15-,16-;/m0./s1

Upstream product

• 195532-54-8 ethyl 8-cyano-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate 
• 209401-69-4 base 1S,6S-2-oxa-5,8-diazabicyclo[4.3.0]nonane 
• 1159908-27-6 C₂₅H₂₇FN₄O₆ 

Relevant articles and documents

A novel approach to Finafloxacin hydrochloride (BAY35-3377)

Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 19 was prepared by a new route. The chiral (S,S′)-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis.