209343-94-2

Upstream product

• 209344-14-9 tert-butyl 3-[4-(1-piperazinyl)phenyl]propionate 
• 103790-48-3 1-tert-butyl 3-(4-aminophenyl)propionate 
• 1194-02-1 4-fluorobenzonitrile 
• 209344-15-0 tert-butyl 3-{4-[4-(4-cyanophenyl)-1-piperazinyl]phenyl}-propionate 

Relevant academic research and scientific papers

Design and synthesis of an orally active GPIIb/IIIa antagonist based on a phenylpiperazine scaffold

The design and synthesis of an orally active LMW non-peptide GPIIb/IIIa antagonist, based on a N,N'-bisphenylpiperazine scaffold, is described. The optimal compound showed a high in vitro binding potency (pIC50=8.7) in combination with potent oral antithrombotic activity (30-40% inhibition of thrombus growth at 0.3-3 mg/kg) with a duration of action of >90 min. in a hamster cheek pouch model.

Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them

Compounds having fibrinogen receptor-antagonistic activity, of the general formula I STR1 in which Z is oxygen or a methylene group, B is a phenyl or pyridyl radical, R1 is hydrogen or a group forming a biolabile ester, and their physiologicall