209476-19-7Relevant academic research and scientific papers
Efficient chromatography-free synthesis of the oxy-analogue of fingolimod
Zivkovic, Aleksandra,Stark, Holger
supporting information; experimental part, p. 3769 - 3771 (2010/08/20)
Fingolimod (FTY720) and its analogue derivatives are not only promising therapeutics in sphingolipid signaling but also valuable tools for understanding the roles of sphingolipids in (patho)physiological conditions. A practical method for the synthesis of the ether analogue of FTY720 is described. Our final synthetic approach allows high yield and efficient synthesis of O-FTY in only four steps without chromatographic purifications.
