5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride is a chemical compound that functions as a 5-Hydroxytryptamine6 (5-HT6) receptor antagonist. This molecule is characterized by its ability to selectively bind to and block the 5-HT6 receptor, which is a subtype of the serotonin receptor family. The compound is structurally complex, featuring a benzothiophene core with various substituents that contribute to its antagonistic properties.
209481-24-3
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Basic information
- Product Name: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
- Synonyms: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride;SB 271046A;Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-, Monohydrochloride;5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride;4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide
- CAS NO:209481-24-3
- Molecular Formula: C20H22ClN3O3S2.HCl
- Molecular Weight: 488.45092
- EINECS: N/A
- Product Categories: N/A
- Mol File: 209481-24-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 664.3°C at 760 mmHg
- Flash Point: 355.5°C
- Appearance: /
- Density: N/A
- Vapor Pressure: 1.63E-17mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: >20mg/mL
- CAS DataBase Reference: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride(209481-24-3)
- EPA Substance Registry System: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride(209481-24-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: nwg
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 209481-24-3(Hazardous Substances Data)
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209481-24-3 Usage
Uses
Used in Pharmaceutical Industry:5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride is used as a 5-HT6 receptor antagonist for the development of novel therapeutics targeting various neurological and psychiatric disorders. The application reason is based on the role of 5-HT6 receptors in cognitive functions, such as learning and memory, as well as their involvement in the regulation of mood and appetite. By blocking these receptors, the compound may help in the treatment of conditions like Alzheimer's disease, schizophrenia, and major depressive disorder.
Used in Research and Development:
In the field of research and development, 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride serves as a valuable tool for studying the function and mechanisms of 5-HT6 receptors. The compound can be used in various experimental setups, such as in vitro binding assays and in vivo animal models, to investigate the receptor's role in different physiological and pathological processes. This knowledge can contribute to the development of more targeted and effective treatments for a range of conditions.
Used in Drug Design and Optimization:
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride can be employed as a lead compound in the design and optimization of new drugs with improved 5-HT6 receptor antagonistic properties. By analyzing the structure-activity relationship of 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride, researchers can identify key structural features that contribute to its antagonistic activity and use this information to design more potent and selective 5-HT6 receptor antagonists.
Check Digit Verification of cas no
The CAS Registry Mumber 209481-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,9,4,8 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.Calculate Digit Verification of CAS Registry Number 209481-24:
(8*2)+(7*0)+(6*9)+(5*4)+(4*8)+(3*1)+(2*2)+(1*4)=133
133 % 10 = 3
So 209481-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H22ClN3O3S2.ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24;/h3-6,11-12,22-23H,7-10H2,1-2H3;1H
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5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
