209481-70-9

Basic information

• Product Name: naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide
• Synonyms: naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide
• CAS NO: 209481-70-9
• Molecular Weight: 381.499
• Mol File: 209481-70-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide(CAS DataBase Reference)
• NIST Chemistry Reference: naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide(209481-70-9)
• EPA Substance Registry System: naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]amide(209481-70-9)

Safety Data

• Hazardous Substances Data: 209481-70-9(Hazardous Substances Data)

Upstream product

• 93-11-8 2-Naphthalenesulfonyl chloride 
• 148546-99-0 3-(4-methylpiperazin-1-yl)aniline 

Downstream Products

• 1240529-79-6 naphthalene-2-sulfonic acid methyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-86-5 naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl](pyridin-3-ylmethyl)amide 
• 1240529-85-4 naphthalene-2-sulfonic acid benzyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-82-1 naphthalene-2-sulfonic acid cyclopropylmethyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-81-0 naphthalene-2-sulfonic acid ethyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-80-9 naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]propylamide 

Relevant articles and documents

Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: A novel series of atypical antipsychotic agents

(Piperazin-1-yl-phenyl)-arylsulfonamides were synthesized and identified to show high affinities for both 5-HT2C and 5-HT6 receptors. Among them, naphthalene-2-sulfonic acid isopropyl-[3-(4-methyl-piperazin-1-yl)- phenyl]-amide (6b) exhibits the highest affinity towards both 5-HT2C (IC50 = 4 nM) and 5-HT6 receptors (IC50 = 3 nM) with good selectivity over other serotonin (5-HT1A, 5-HT 2A, and 5-HT7) and dopamine (D2-D4) receptor subtypes. In 5-HT2C and 5-HT6 receptor functional assays, this compound showed considerable antagonistic activity for both receptors.