209481-70-9

Upstream product

• 93-11-8 2-Naphthalenesulfonyl chloride 
• 148546-99-0 3-(4-methylpiperazin-1-yl)aniline 

Downstream Products

• 1240529-79-6 naphthalene-2-sulfonic acid methyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-86-5 naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl](pyridin-3-ylmethyl)amide 
• 1240529-85-4 naphthalene-2-sulfonic acid benzyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-82-1 naphthalene-2-sulfonic acid cyclopropylmethyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-81-0 naphthalene-2-sulfonic acid ethyl[3-(4-methylpiperazin-1-yl)phenyl]amide 
• 1240529-80-9 naphthalene-2-sulfonic acid [3-(4-methylpiperazin-1-yl)phenyl]propylamide 

Relevant academic research and scientific papers

Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: A novel series of atypical antipsychotic agents

(Piperazin-1-yl-phenyl)-arylsulfonamides were synthesized and identified to show high affinities for both 5-HT2C and 5-HT6 receptors. Among them, naphthalene-2-sulfonic acid isopropyl-[3-(4-methyl-piperazin-1-yl)- phenyl]-amide (6b) exhibits the highest affinity towards both 5-HT2C (IC50 = 4 nM) and 5-HT6 receptors (IC50 = 3 nM) with good selectivity over other serotonin (5-HT1A, 5-HT 2A, and 5-HT7) and dopamine (D2-D4) receptor subtypes. In 5-HT2C and 5-HT6 receptor functional assays, this compound showed considerable antagonistic activity for both receptors.

Sulphonamide derivatives, process for their preparation, and their use as medicaments

Novel sulphonamide derivatives having CNS activity, processes for their preparation and their use as medicaments are disclosed. The present compounds are of formula (I) or a salt thereof: wherein: P isbenzothiophene, benzothiadiazole, quinoline, benzofuran or indole; A is a single bond, a C1-6alkylene or a C1-6alkenylene group; R1is halogen, C1-6alkyl optionally substituted by one or more halogen atoms, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, OCF3, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, nitro, amino, C1-6alkylamino or C1-6dialkylamino, cyano or R1is phenyl or naphthyl; n is 0, 1, 2, 3, 4, 5, or 6; R2is hydrogen, C1-6alkyl or aryl C1-6alkyl or R2is linked to R3to form a group (CH2)2or (CH2)3; R3is a group R5or together with R5forms a group (CH2)2O or (CH2)3O or R3is linked to R2to form a group (CH2)2or (CH2)3; R4is an N-piperazine ring optionally substituted by C1-6alkyl; and R5is hydrogen, halogen, C1-6alkyl, C3-6cycloalkyl, COC1-6alkyl, C1-6alkoxy, hydroxy, hydroxyC1-6alkyl, hydroxyC1-6alkoxy, C1-6alkoxyC1-6alkoxy, nitro, trifluoromethyl, cyano or aryl.