209482-07-5

Usage

General Description

1H-Indole, 2,3-dihydro-6-(4-methyl-1-piperazinyl)-, also known as quetiapine, is a medication used to treat bipolar disorder and schizophrenia. It works by balancing certain natural substances in the brain called neurotransmitters. Quetiapine belongs to a class of drugs known as atypical antipsychotics. It is thought to affect serotonin and dopamine, two of the major neurotransmitters in the brain. Quetiapine is available in tablet form and is usually taken once or twice a day with or without food. It is important to take this medication exactly as prescribed by a doctor and to not stop taking it without consulting a healthcare professional. Common side effects may include drowsiness, dizziness, and weight gain.

Upstream product

• 51-75-2 nitrogen mustard 
• 62368-29-0 1-acetyl-6-aminoindoline 
• 215162-97-3 C₁₅H₂₁N₃O 
• 321745-04-4 6-(4-methylpiperazin-1-yl)-1H-indole 

Relevant academic research and scientific papers

A divergent SAR study allows optimization of a potent 5-HT2c inhibitor to a promising antimalarial scaffold

From the 13-533 chemical structures published by GlaxoSmithKline in 2010, we identified 47 quality starting points for lead optimization. One of the most promising hits was the TCMDC-139046, a molecule presenting an indoline core, which is well-known for its anxiolytic properties by interacting with serotonin antagonist receptors 5-HT2. The inhibition of this target will complicate the clinical development of these compounds as antimalarials. Herein, we present the antimalarial profile of this series and our efforts to avoid interaction with this receptor, while maintaining a good antiparasitic potency. By using a double-divergent structure-activity relationship analysis, we have obtained a novel lead compound harboring an indoline core.