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((3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone is a complex organic compound characterized by a molecular structure that includes a piperazine ring, a benzoyl group, a chlorophenyl group, and a pyrazolopyridinone group. ((3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone is considered a potential pharmacological agent, likely to exhibit activity within the central nervous system due to its structural features.
Used in Pharmaceutical Industry:
((3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone is used as a potential pharmacological agent for its possible activity in the central nervous system. Its specific application and efficacy are yet to be determined through further research and development.
Used in Research and Development:
In the field of scientific research, ((3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazin-1-yl)(6-bromopyrazolo[1,5-a]pyridin-3-yl)methanone serves as a subject for investigation to explore its chemical properties, reactivity, and potential applications in various settings, including medicinal chemistry and drug discovery.

2095677-20-4

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2095677-20-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2095677-20-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,9,5,6,7 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2095677-20:
(9*2)+(8*0)+(7*9)+(6*5)+(5*6)+(4*7)+(3*7)+(2*2)+(1*0)=194
194 % 10 = 4
So 2095677-20-4 is a valid CAS Registry Number.

2095677-20-4Downstream Products

2095677-20-4Relevant academic research and scientific papers

Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors

Mizojiri, Ryo,Nakata, Daisuke,Satoh, Yoshihiko,Morishita, Daisuke,Shibata, Sachio,Iwatani-Yoshihara, Misa,Kosugi, Yohei,Kosaka, Mai,Takeda, Junpei,Sasaki, Shigekazu,Takami, Kazuaki,Fukuda, Koichiro,Kamaura, Masahiro,Sasaki, Shinobu,Arai, Ryosuke,Cary, Douglas R.,Imaeda, Yasuhiro

, p. 1077 - 1082 (2017)

Starting from our previous eIF4A3-selective inhibitor 1a, a novel series of (piperazine-1-carbonyl)pyridin-2(1H)-one derivatives was designed, synthesized, and evaluated for identification of orally bioavailable probe molecules. Compounds 1o and 1q showed improved physicochemical and ADMET profiles, while maintaining potent and subtype-selective eIF4A3 inhibitory potency. In accord with their promising PK profiles and results from initial in vivo PD studies, compounds 1o and 1q showed antitumor efficacy with T/C values of 54% and 29%, respectively, without severe body weight loss. Thus, our novel series of compounds represents promising probe molecules for the in vivo pharmacological study of selective eIF4A3 inhibition.

Heterocyclic compounds

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Paragraph 0193, (2018/04/20)

[A] compounds useful in treating or preventing cancer containing a drug. The present invention is [a], formula (I):[In the formula, each symbol is as defined herein. ]The compound or its salt represented by the related. [Drawing] no

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