20958-17-2

Usage

Uses

Used in Organic Synthesis:
4,8-Dimethylphenanthro[3,2-b]furan-7,11-dione is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for multiple points of reactivity, facilitating the synthesis of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4,8-Dimethylphenanthro[3,2-b]furan-7,11-dione is utilized as a precursor for the development of pharmaceutical compounds. Its potential reactivity and the presence of a furan ring can contribute to the design of novel drugs with specific therapeutic properties.
Used in Research and Development:
4,8-Dimethylphenanthro[3,2-b]furan-7,11-dione serves as a valuable compound in research and development settings, where its unique structure and properties are explored for new applications and to understand its reactivity and interactions with other molecules.
Used in Chemical Industry:
Within the chemical industry, 4,8-Dimethylphenanthro[3,2-b]furan-7,11-dione may be employed as a specialty chemical in the production of dyes, pigments, or other materials that require its specific structural attributes.

Upstream product

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• 78-95-5 chloroacetone 
• 1601369-91-8 3-bromo-5-methoxy-2-((2-methylphenyl)ethyl)cyclohexa-2,5-diene-1,4-dione 

Relevant academic research and scientific papers

Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish

During inflammation, dysregulated neutrophil behaviour can play a major role in a range of chronic inflammatory diseases, for many of which current treatments are generally ineffective. Recently, specific naturally occurring tanshinones have shown promising anti-inflammatory effects by targeting neutrophils in vivo, yet such tanshinones, and moreover, their isomeric isotanshinone counterparts, are still a largely underexplored class of compounds, both in terms of synthesis and biological effects. To explore the anti-inflammatory effects of isotanshinones, and the tanshinones more generally, a series of substituted tanshinone and isotanshinone analogues was synthesised, alongside other structurally similar molecules. Evaluation of these using a transgenic zebrafish model of neutrophilic inflammation revealed differential anti-inflammatory profiles in vivo, with a number of compounds exhibiting promising effects. Several compounds reduce initial neutrophil recruitment and/or promote resolution of neutrophilic inflammation, of which two also result in increased apoptosis of human neutrophils. In particular, the methoxy-substituted tanshinone 39 specifically accelerates resolution of inflammation without affecting the recruitment of neutrophils to inflammatory sites, making this a particularly attractive candidate for potential pro-resolution therapeutics, as well as a possible lead for future development of functionalised tanshinones as molecular tools and/or chemical probes. The structurally related β-lapachones promote neutrophil recruitment but do not affect resolution. We also observed notable differences in toxicity profiles between compound classes. Overall, we provide new insights into the in vivo anti-inflammatory activities of several novel tanshinones, isotanshinones, and structurally related compounds.