209608-40-2

Upstream product

• 109-01-3 1-methyl-piperazine 
• 209608-38-8 4-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-butyric acid methyl ester 
• 209608-37-7 4-[3-(4-Bromo-2-nitro-phenylsulfanyl)-phenylcarbamoyl]-butyric acid 
• 188059-02-1 [3-(4-bromo-2-nitro)phenylsulfanyl]phenylamine 
• 209608-39-9 4-[3-(2-Amino-4-bromo-phenylsulfanyl)-phenylcarbamoyl]-butyric acid methyl ester 
• 22948-02-3 3-aminothiophenol 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 

Downstream Products

• 209608-41-3 4-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-butyric acid 

Relevant academic research and scientific papers

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi

In order to establish structural elements responsible for inhibition of trypanothione reductase (TR) from TrypanosoMa cruzi by 2- aminodiphenylsulfides, a series of dissymmetrical derivatives, corresponding to the replacement of one aromatic moiety by different amines, was synthesized. TR inhibition studies revealed the importance of the aromatic rings and of the amino groups in the side chains for potent inhibition. Quinonic moities were also introduced with the aim of acting as TR redox- cycling substrates.