209625-75-2Relevant academic research and scientific papers
The first enantioselective syntheses of vicinal difluoropyrrolidines and the first catalytic asymmetric synthesis mediated by the C2 symmetry of a -CHFCHF- Unit
Marson, Charles M.,Melling, Robert C.
, p. 1223 - 1224 (2007/10/03)
The first enantiopure vicinal difluorides of C2 symmetry have been prepared by the introduction of fluorine at both centres in a single operation; the first asymmetric synthesis using a catalyst whose chirality depends on organofluorine asymmetry is described.
ASYMMETRIC HYDROGENATIONS CATALYSED BY DIPHOSPHINITE RHODIUM COMPLEXES DERIVED FROM NATURAL TARTARIC ACID
Bourson, Jean,Oliveros, Laureano
, p. 77 - 84 (2007/10/02)
Two chiral diphosphinites, derived from natural tartaric acid, have been prepared and used as ligands for the preparation of two asymmetric hydrogenation catalysts, which were isolated in a crystalline state.After several weeks storage, these catalysts are still effective in the asymmetric hydrogenation of α-acetamido- and α-benzamido-cinnamic acid, citraconic acid, 2-phenyl-1-butene.In the hydrogenation of amino acid precursors the optical yields ranged from 14 to 44percent.Starting from a given substrate, each of the two enantiomers can be obtained by appropriate choice of one of our two catalysts, which are thus complementary to each other.The influence on the optical yield of various factors in the hydrogenations are considered.
