209682-78-0Relevant academic research and scientific papers
5-Alkyltryptamine derivatives as highly selective and potent 5-HT(1D) receptor agonists
Slassi, Abdelmalik,Edwards, Louise,O'Brien, Anne,Meng, Charles Q.,Xin, Tao,Seto, Caroline,Lee, David K.H.,MacLean, Neil,Hynd, Donna,Chen, Cora,Wang, Hong,Kamboj, Rajender,Rakhit, Suman
, p. 1707 - 1709 (2007/10/03)
A series of 5-alkyltryptamines (6) and the corresponding conformationally constrained analogues (8) have been synthesized. The structure-activity relationships (SAR) at the 5-position of the indole skeleton and the ethylamine side chain have been studied.
5-ALKYL INDOLE COMPOUNDS
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, (2008/06/13)
Described herein are compounds selective for the 5-HT 1D-like receptor, which have the general formula: STR1 wherein: R 1 is linear or branched loweralkyl;R 2 is selected from a group of Formula II, III, IV and V: STR2 R 3 is selected from H and loweralkyl; R 4 is selected from H and loweralkyl; One of R. sup. 5 and R 6 is H and the other is independently selected from H, loweralkoxy, loweralkyl and hydroxy; andn is 1-3; or a salt, solvate or hydrate thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of the 5-HT 1D-like receptor is implicated, such as migraine.
