209727-99-1

Basic information

• Product Name: (S)-2,3-isopropylidenedioxyprop-1-yl 3-nitrobenzenesulfonate
• Synonyms: (S)-2,3-isopropylidenedioxyprop-1-yl 3-nitrobenzenesulfonate
• CAS NO: 209727-99-1
• Molecular Weight: 317.32
• Mol File: 209727-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2,3-isopropylidenedioxyprop-1-yl 3-nitrobenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2,3-isopropylidenedioxyprop-1-yl 3-nitrobenzenesulfonate(209727-99-1)
• EPA Substance Registry System: (S)-2,3-isopropylidenedioxyprop-1-yl 3-nitrobenzenesulfonate(209727-99-1)

Safety Data

• Hazardous Substances Data: 209727-99-1(Hazardous Substances Data)

Upstream product

• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 

Downstream Products

• 209728-00-7 (S)-1-(1H-indol-4-yloxy)-2,3-isopropylidenedioxypropane 

Relevant articles and documents

Synthesis of (S)-1-(1H-indol-4-yloxy)-3[4-(3-methoxyphenyl)-4- hydroxypiperidin-1-yl]-propan-2-ol (LY333068) succinate, and its 3-[14C]- isotopomer based on chiral glycerol-[14C] derivatives

The 3-[14C]-isotopomer of (S)-1-(1H-indol-4-yloxy)-3-[4-(3- methoxyphenyl)-4-hydroxypiperidin-1-yl]-propan-2-ol (LY333068), a 5HT(1A) antagonist, was prepared in 10 steps and 8.2% radiochemical yield from (L)- serine-[3-14C]. Deamination, esterification, and protection of the resulting diol gave methyl (R)2,2-dimethyl-1,3-dioxolane-4-carboxylate-[3- 14C], as a chiral and radiolabeled building block, which then was subsequently coupled with 4-hydroxyindole and 4-(3-methoxyphenyl)-4- hydroxypiperidine to give the titled product with 99.4% radiochemical purity.