209731-38-4Relevant articles and documents
Isoxazolines and Isoxazoles as Factor Xa inhibitors
Pruitt, James R.,Pinto, Donald J.,Estrella, Melissa J.,Bostrom, Lori L.,Knabb, Robert M.,Wong, Pancras C.,Wright, Matthew R.,Wexler, Ruth R.
, p. 685 - 689 (2007/10/03)
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis. (C) 2000 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.