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Usage

Uses

Used in Cancer Research:
VH298 is used as a research tool for studying the role of VHL and HIF-α in cancer development and progression. Its ability to stabilize HIF-α and block the VHL:HIF-α interaction makes it a valuable compound for understanding the underlying mechanisms of hypoxia in cancer cells.
Used in Drug Development:
VH298 is used as a lead compound in the development of new therapeutics targeting the VHL-HIF-α pathway. Its potent inhibition of VHL E3 ligase activity and stabilization of HIF-α can potentially be leveraged to develop drugs that interfere with hypoxia-associated signaling in cancer cells, leading to novel treatment strategies.
Used in PROTAC Technology:
VH298 is used as a component in the development of targeted protein degradation therapies using PROTAC technology. Its ability to block the VHL:HIF-α interaction can be exploited to design molecules that promote the degradation of specific proteins, offering a new approach to treating various diseases, including cancer.
Used in Hypoxic Response Studies:
VH298 is used as a chemical probe to investigate the role of hypoxic response in cellular processes and disease states. By stabilizing HIF-α and initiating a hypoxic response, VH298 can help researchers understand the cellular adaptations to low oxygen conditions and their implications in various pathologies.

In vitro

VH298 can activate the HIF-1 signalling pathway by stabilizing both forms of HIF-1α in vitro. VH298 promotes rFb variability, migration, and synthesis of collagen and regulatory cell factors. VH298 improves the angiogenesis of hUVEC.

In vivo

VH298 can activate the HIF-1 signalling pathway by stabilizing both forms of HIF-1α in vitro. VH298 promotes rFb variability, migration, and synthesis of collagen and regulatory cell factors. VH298 improves the angiogenesis of hUVEC.