209787-88-2Relevant academic research and scientific papers
Chiral β-amino sulfoxides. Synthesis, configurational assignment and conformational analysis based on X-ray, CD, 1H NMR and theoretical calculations
Lewanowicz,Lipinski,Siedlecka,Skarzewski,Baert
, p. 6571 - 6586 (1998)
Enantiomerically pure u and l β-amino sulfoxides have been easily obtained from the respective homochiral α-amino alcohols. The absolute configuration at the created stereogenic centre was assigned by CD spectra and by X-ray analysis. Conformational analysis of the title compounds was carried out using quantum chemical energy-geometry optimization. Thus established conformational behavior explained the strongly configuration dependent NMR spectral patterns observed for the u and l diastereomers.
CHIRAL AMINE-CATALYZED ASYMMETRIC ADDITION OF CARBON-CENTERED NUCLEOPHILES TO IMINES
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Page/Page column 60-61, (2010/11/25)
The present invention relates to an asymmetric synthesis useful for preparing compounds useful for the treatment of cardiovascular diseases and for studying the role of motor proteins in cell cycle progression.
