209796-49-6

Upstream product

• 336870-02-1 (S)-tert-butoxycarbonylamino-(trans-4-hydroxy-cyclohexyl)-acetic acid 

Downstream Products

• 912345-75-6 (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-amide 
• 908140-21-6 (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-amide 
• 908139-32-2 (6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid {(S)-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-amide 
• 908128-09-6 [1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-(4-methyl-5-vinyl-thiazol-2-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester 
• 908128-00-7 {2-benzothiazol-2-yl-1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-ethyl}-carbamic acid tert-butyl ester 
• 908127-99-1 {1-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-2-oxo-2-thiazol-2-yl-ethyl}-carbamic acid tert-butyl ester 
• 209796-51-0 {(methoxy-methyl-carbamoyl)-[4-(4-methoxy-2,3,6-trimethyl-benzenesulfonylamino)-cyclohexyl]-methyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: Transition state inhibitors

Bicyclic piperazinone based thrombin inhibitors of general structure 2 were prepared and evaluated in vitro and in vivo. These inhibitors, having in common an electrophilic basic trans-cyclohexylamine P1 residue, displayed high thrombin affinity, high selectivity against trypsin and good in vivo efficacy in the rat arterial thrombosis model.