209798-66-3

Basic information

• Product Name: 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-bromophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione
• Synonyms: 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-bromophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione
• CAS NO: 209798-66-3
• Molecular Weight: 473.317
• Mol File: 209798-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-bromophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-bromophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione(209798-66-3)
• EPA Substance Registry System: 7,7-bis(dimethylamino)-6,6-difluoro-1,3-dimethyl-5-(4'-bromophenyl)-1,3,4,5,6,7-hexahydro-2H-pyrano[2,3-d]pyrimidine-2,4-dione(209798-66-3)

Safety Data

• Hazardous Substances Data: 209798-66-3(Hazardous Substances Data)

Upstream product

• 188429-64-3 2,2,2-trifluoro-N,N,N',N'-tetramethylethane-1,1-diamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 769-42-6 1,3-dimethylbarbituric acid 
• 29922-14-3 1,1-bis(dimethylamino)-2,2-difluoroethene 
• 57270-85-6 5-(4-bromobenzylidene)-1,3-dimethylpyrimidine-2,4,6-trione 

Downstream Products

• 209798-74-3 3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-bromophenyl)propanoic acid 
• 209798-70-9 N,N-dimethyl-3-(1,3-dimethyl-2,4,6-trioxohexahydro-5-pyrimidinyl)-2,2-difluoro-3-(4-bromophenyl)propanamide 

Relevant articles and documents

Synthesis of novel fluorinated derivatives of 1,3-dimethylbarbituric acid

Synthetic utility of the novel difluoro ketene aminal 1 was extended to the preparation of a number of potentially biologically-interesting difluoro barbituric acid derivatives via initial hetero-Diels-Alder reactions of 1 with p-substituted-5-benzylidene-1,3-dimethylbarbituric acids 3. These cycloadducts 4 upon hydrolysis, provided the formal Michael addition product amides 5 which were readily converted to the respective carboxylic acids 6. The acids were dehydratively cyclized to form novel bicyclic lactones 8.