209808-01-5

Upstream product

• 25519-80-6 4-(benzoyl)piperidine hydrochloride 
• 193217-39-9 1-(t-butoxycarbonyl)-4-(benzoyl)piperidine 
• 193217-40-2 4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)benzyl)-N,N-diethylbenzamide 

Downstream Products

• 209807-48-7 N,N-diethyl-4-[(N-2,4-dichlorobenzyl)-phenyl-piperidin-4-ylidene-methyl]-benzamide 
• 209807-41-0 N,N-Diethyl-4-(4-chlorophenyl-piperidin-4-ylidene-methyl)-benzamide 
• 209807-47-6 N,N-diethyl-4-[(N-4-methoxybenzyl)-phenyl-piperidin-4-ylidene-methyl]-benzamide 

Relevant academic research and scientific papers

Compounds with analgesic effect

Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent δ opioid receptor agonist with oral bioavailability and its analogues

The design, synthesis, and pharmacological evaluation of a novel class of δ opioid receptor agonists, N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (2) by repl