209852-85-7

Upstream product

• 994-30-9 triethylsilyl chloride 
• 209852-83-5 rac-1-Methoxy-1-(1-phenylethoxy)propan-2-one 
• 98-85-1 1-Phenylethanol 

Relevant academic research and scientific papers

Chiral Allyl Cations Are Capture by Furan with 100% Stereoselectivity: Synthesis of Enantiopure 2-Alkoxy-8-oxabicyclo[3.2.1]oct-6-en-3-ones by Low-Temperature [4+3] Cycloaddition

A low-temperature (-95°C) protocol for intermolecular cycloadditions of furan to chiral silyloxyallyl cations in dichloromethane is described. Key precursors are open-chain, mixed α-ketoacetals, which are chiral. The resulting [4+3] cycloadducts are dense

Chiral allyl cations in cycloadditions to furan: Synthesis of 2-(1'-phenylethoxy)-8-oxabicyclo[3.2.1]oct-6-en-3-one in high enantiomeric purity

Efficient shielding of the π face is offered by the phenyl group of the chiral auxiliary (TES = triethylsilyl) to the allyl cation generated at low temperature from 1. This protection induces high π-facial selectivity and allows high chemical yield on the capture of the cation by furan to afford the title cycloadduct 2.