209958-42-9

Basic information

• Product Name: N-Boc-4-Bromo-2-fluoroaniline
• Synonyms: (4-Bromo-2-fluorophenyl)carbamic acid tert-butyl ester;N-Boc-4-Bromo-2-fluoroaniline;tert-Butyl N-(4-bromo-2-fluorophenyl)carbamate;Carbamic acid, N-(4-bromo-2-fluorophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 209958-42-9
• Molecular Formula: C₁₁H₁₃BrFNO₂
• Molecular Weight: 290.13
• Mol File: 209958-42-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 272.239°C at 760 mmHg
• Flash Point: 118.446°C
• Appearance: /
• Density: 1.459g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: 2-8°C
• PKA: 11.90±0.70(Predicted)
• CAS DataBase Reference: N-Boc-4-Bromo-2-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-4-Bromo-2-fluoroaniline(209958-42-9)
• EPA Substance Registry System: N-Boc-4-Bromo-2-fluoroaniline(209958-42-9)

Safety Data

• Hazardous Substances Data: 209958-42-9(Hazardous Substances Data)

Usage

General Description

N-Boc-4-Bromo-2-fluoroaniline is a chemical compound with the molecular formula C11H12BrFN2O2. N-Boc-4-Bromo-2-fluoroaniline belongs to the class of organic compounds known as N-acylaniline. N-acylaniline are acylated aniline derivatives containing an acylaniline moiety. It is used primarily as a building block in organic synthesis, including the synthesis of pharmaceuticals and other bioactive compounds. It contains both bromine and fluorine atoms, which are highly reactive and can be used to introduce a variety of functional groups in chemical reactions. Its Boc (tert-butoxycarbonyl) group is a protective group commonly used in organic chemistry, particularly peptide synthesis.

InChI:InChI=1/C11H13BrFNO2/c1-11(2,3)16-10(15)14-9-5-4-7(12)6-8(9)13/h4-6H,1-3H3,(H,14,15)

Upstream product

• 75-09-2 dichloromethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 367-24-8 4-bromo-2-fluoroaniline 

Downstream Products

• 218301-87-2 4-(tert-butoxycarbonylamino)-3-fluorophenylboronic acid 
• 819058-34-9 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 262444-42-8 tert-butyl N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate 
• 870545-80-5 C₃₁H₃₃FN₄O₂ 
• 1293979-48-2 C₁₅H₁₉FN₂O₂ 
• 1293979-49-3 C₁₅H₂₁FN₂O₂ 
• 1293979-64-2 C₂₀H₂₈FN₃O₃ 
• 1293979-65-3 C₁₅H₂₀FN₃O 
• 1293979-59-5 C₂₄H₂₃ClFN₃O₃S 
• 1293979-58-4 C₂₄H₂₃ClFN₃O₃S 
• 1293979-57-3 C₂₀H₂₁ClFN₃O₃S₂ 
• 1293979-56-2 C₂₀H₂₁ClFN₃O₃S₂ 
• 1212991-05-3 C₁₀H₁₃FN₂ 

Relevant articles and documents

DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

Bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

1,3,4-OXADIAZOLE DERIVATIVES AND THEIR USES TO TREAT DIABETES

DGAT-1 inhibitor compounds of formula (I) and pharmaceutically-acceptable salts thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity (I) wherein n is 0, 1, 2 or 3, R is independently selected from fluoro, chloro, bromo, trifluoromethyl, methoxy, difluoromethoxy and trifluoromethoxy and Z is carboxy or a mimic or bioisostere thereof, hydroxyl, hydroxymethyl, or ?CONRbRc wherein Rb and Rc are independently selected from hydrogen and (1-4C)alkyl, which (1-4C)alkyl group may be optionally substituted by carboxy or a mimic or bioisostere thereof.

Substituted sulphoximines as Tie2 inhibitors and salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same and uses of the same

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