209959-33-1

Basic information

• Product Name: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE
• Synonyms: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE;2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE, 95+%;2-(N,N-BisBOC-Amino)-5-bromopyrimidine;2-Amino-5-bromopyrimidine, 2,2-Bis-BOC protected;tert-butyl N-(5-broMopyriMidin-2-yl)-N-[(tert-butoxy)carbonyl]carbaMate;(5-Bromopyrimidin-2-yl)bis(tert-butoxycarbonyl)amine;Imidodicarbonic acid 2-(5-bromo-2-pyrimidinyl)-1,3-bis(1,1-dimethylethyl) ester;N,N-bis-Boc-2-aMino-5-broMopyriMidine
• CAS NO: 209959-33-1
• Molecular Formula: C₁₄H₂₀BrN₃O₄
• Molecular Weight: 374.23
• Product Categories: API intermediates;pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 209959-33-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 415.197oC at 760 mmHg
• Flash Point: 204.904oC
• Appearance: /
• Density: 1.390
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.49±0.10(Predicted)
• CAS DataBase Reference: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE(209959-33-1)
• EPA Substance Registry System: 2-[BIS(TERT-BUTOXYCARBONYL)AMINO]-5-BROMOPYRIMIDINE(209959-33-1)

Safety Data

• Hazardous Substances Data: 209959-33-1(Hazardous Substances Data)

Usage

General Description

2-[Bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine is a chemical compound with the molecular formula C14H20N4O4Br. It is a derivative of pyrimidine, and its structure contains a pyrimidine ring with a bromine atom at the 5th position. The compound also has two tert-butoxycarbonyl (t-Boc) groups attached to the amino group of the pyrimidine ring. These groups are commonly used as protective groups in organic synthesis to prevent unwanted reactions. 2-[Bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a white to off-white solid with a molecular weight of 370.24 g/mol.

InChI:InChI=1/C14H20BrN3O4/c1-13(2,3)21-11(19)18(12(20)22-14(4,5)6)10-16-7-9(15)8-17-10/h7-8H,1-6H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 7752-82-1 5-bromo-2-aminopyrimidine 

Downstream Products

• 883231-23-0 tert-butyl (5-bromopyrimidin-2-yl)carbamate 
• 914377-34-7 2-(5-hydroxy-2-pyrimidinyl)imidodicarbonic acid 1,3-bis(1,1-dimethylethyl)ester 

Relevant articles and documents

4-ETHYLNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS

The invention relates to compounds of formula I, wherein the substituents are as defined in more detail in the description. The compounds are potent inhibitors of GCN2 and have excellent pharmacokinetic properties. Compounds are useful for the treatment or prevention of various conditions, especially cancer. The invention further relates to pharmaceutical compositions comprising the compounds of the invention and uses of the compounds and compositions.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.